|Product name||Thyroid papillary carcinom|
|No. of samples||1|
|Description||thyroid, papillary carcinoma
Age/Sex : 68/F
Product Related Literature
Papillary thyroid carcinoma and papillary thyroid cancer is the most common type of thyroid cancer, which accounts for 75% to 85% of all cases of cancer of the thyroid gland. In the age group of 20-55 years, a present of a woman, it occurs more often. In addition, as well as cancer of the thyroid, cancer in children in thyroid cancer patients who have undergone previous radiation (core and uniform color scheme is empty) Ani neck. Characteristic orphan nuclear inclusion of head and eye grain of sand body and the optical microscope is the predominant type. First, it is useful to identify the follicular variant of papillary thyroid cancer. Lymphatic circulation is a more frequently than is lymph node metastasis of papillary thyroid cancer is actually blood circulation spread of so-called atypical side thyroid.
Small papillary cancer is a subset of papillary thyroid cancer is defined as equal to 1 CM or smaller. The incidence of papillary thyroid cancer in small autopsy series reported by Harach from the highest. You have the associated micro cancer in 1985 that found 36 of the anatomy that has 101 continuous. And Michael Pakdaman. The reported incidence highest retrospective surgical series 49.9% 860 cases. Range of a single observation from radioactive iodine ablation and total thyroidectomy (confirmed by FNAB) and management strategy for incidental papillary micro carcinoma in ultrasonography. And Harach. recommended to use the term “occult papillary tumor” in order to avoid giving the patient suffering cancer.It was so Woolner and others. and coined the term “occult papillary carcinoma” in 1960 for anyone to describe a 1,5 cm diameter ≤ papillary cancer in any first.
The papillary carcinoma tends to invade the lymphatics, but it is difficult to interfere with the blood vessel. These types of tumors are not encapsulated most common because of insufficient they spread to the regional lymph nodes, it is possible diagnosis of malignant tissue to generate a cystic structure near difficult thyroid have a high tendency. Further, Highfield papillary tumors and metastases to the lungs, or lead to multiple nodes can be can show snowflake whole. EM showed an increase in mitochondria increase RER, other features of papillary carcinoma is that the villus apex. Further, papillary cancer, is 40% of the time allocated to the growth and capsules painless.
Primarily two forms of the chromosomal translocation, and mutations associated with papillary thyroid cancer, a form of point mutation. MARK / ERK pathway – these changes will lead to the activation of oncogenic pathway common. Chromosomal translocation, including located on chromosome 10q11, (encoding the receptor tyrosine kinase that plays an essential role in the development of neuroendocrine cells) proto-oncogene RET occurs in about one fifth of papillary thyroid cancer. Is called the (cancer of the nipple / Ret of thyroid) RET / PTC protein, fusion oncogene that is generated, activate the MAPK / ERK pathway downstream of RET and permanently. Frequency of retention / PTC displacement significantly higher in papillary carcinoma that occurs after exposure to radiation and children. (Encoding the receptor TrkA s), NTRK1 gene located on chromosome 1q moves 10% about 5% of papillary thyroid cancer as well. Half of point mutations of papillary thyroid cancer oncogene in port 1 BRAF about 3 minutes, and activation of MAPK / ERK pathway. Mutations of the BRAF V600E mutation is found in these cases. After performing the multivariate analysis, it was found that the only parameter associated with the lack of tumor capsule and BRAF V600E mutation is (P = 0.0005). According to recent studies, the supported teat, tend to have a long-term course more active V600E mutation in common. BRAF mutation is frequently undifferentiated tumor which has been developed from papillary tumor and papillary carcinoma.
Usually, as nodules of asymptomatic thyroid gland appears as a lump in the neck, papillary thyroid cancer has been detected in routine testing. In some cases, it is possible to mass produce local symptoms. Typically, this table is called a (FNA) fine needle aspiration biopsy for investigation. It is the process of FNA accuracy is very high, it is used if it is such a widely. Other methods of investigation is included ultrasound, nuclear scan. Ultrasound is a useful test to identify calcification to distinguish between solids from cystic lesions. Thyroid ultrasound is also very efficient from the relevant microcarcinomas very small cell cancer (<1 cm) of. It was found in papillary thyroid carcinoma hardware nodes, when the cervical lymph nodes are enlarged is found, is there are other parts of the body metastatic lesions unconfirmed, or when located multinodular goiter are. When painful, the extension of lesions found in the thyroid in order to be able to indicate the presence of papillary thyroid cancer, in particular, they have to be considered reliable. It is possible to represent the papillary, clinical symptoms, other tracheal cervical sympathetic or recurrent laryngeal, the hardness of the stone fixed damage.
75% of the population, will have a thyroid nodule of these, and most will always benign. Chest X-rays, is not normally executed. In the case of metastases, some tests the other, is carried out in order to obtain sufficient information before the operation. These tests, which contains the MRI and CAT scan and neck ultrasound. Other features which have shown good results in the definition of relevant results or tumors of -201 chloride thallium helps metastatic tumors to visualize the lymphoma is useful to identify the gallium scan be used, to be useful for imaging MTC is proven, I-meta-iodobenzylguanidine (MIBG) which, Tc-MIBI which was in effect,, PET scanning to detect deposition of metastatic thyroid cancer Is also useful for imaging metastatic disease. And Chia. Reported that it is possible TSHR mRNA to reduce unnecessary operation measured by FNA, and further detect preoperative thyroid cancer in nodules patients early levels to predict the residual / metastatic disease after surgery. Aspect of the X-ray CT or bile duct and / or lung metastases possible, can be diagnosed by cytology of bronchoalveolar lavage fluid samples.