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Thymic carcinoma is a rare cancer of the thymus. Usually, spread the risk of recurrence is high, this is the survival of the poor. are divided into subtypes depending on the type of cells that thymic carcinoma, cancer has begun. It is also known as C-type thymoma. Words multiple endocrine tumors (MEN), and a tumor with each of the endocrine glands, the characteristic pattern of its own, he encompasses a syndrome of some. It is in some cases of malignant tumors in other benign. In benign or malignant tumors of non-endocrine tissue, occur as a component of some tumors these syndromes.

MEN syndrome is inherited as an autosomal dominant disorder. The old name, “disease adenoma endocrine multiple” and “multiple adenomas” (MEA) is replaced by the current term. The term multiple endocrine neoplasia syndrome, and is used when patients two or more types of endocrine tumors that occur as part of a set of male occurs, or the transmission of genetic evidence or mutations caused by some. Because there is a small statistical probability for the development of tumor “sporadic” of two that occur in one of the potential syndrome occurs, the presence of two or more of the tumor in a patient, many men as possible individually automatically Accidents do not bet.

The term “multiple endocrine neoplasia” was introduced in 1968, was from the 1903 description of the date of the condition. Not classified as multiple endocrine neoplasia syndrome officially, but Carney complex and von Hippel-Lindau disease is an autosomal dominant syndrome endocrine tumor of the other two with duplicate function the clinical features of the syndrome of man. It has not been transmitted in the germ, but McCune – Albright syndrome is a genetic syndrome characterized by tumor endocrine function such as duplicate endocrine glands shall be involved in MEN2 or MEN1. Man known as the setting and ME N 3 sometimes vary depending on (see www.ClinicalReview.com) institutions 2B. (Wagenmann-Froboese syndrome Williams Pollock syndrome, and Gorlin Vickers syndrome, for example), indeed, has been proposed for traction enough no gain to be to be worthy of continued use MEN2B additional eponyms vary, but the medical literature Although abandoned,. Initial report of another, and was Schimke. 1968 in.

Format (“MEN4”), the fourth multiple endocrine neoplasia associated with CDKN1B is included in OMIM. I have considered performance so as to overlap with the MEN2 and MEN1. Consists of exons spanning about 10 10 kilobytes, MEN1 gene encodes a protein of 610 amino acids called menin. The last part of exon 10 and the first exon are not converted. Major transcript 2.8 kilobytes are described in reference (pancreas, thymus, adrenal, thyroid, testis, leukocytes, heart, brain, lung, muscle, small intestine, liver, kidney), various additional human tissues suggesting alternative splicing tissue-specific, about 4 kilobytes, have been detected in thymus and pancreas. Menin is a nuclear protein and the saved (75%) Drosophila (47%) from (47-51) distant zebra mouse (98%), and rat (97%) to (67Kda) advanced 610 amino acids. Mouse MEN1 amino acid sequence and the rate of people will be sharing the similarity of 98.4% and identity of 95.8%. Analysis Menin’amino acid sequence showed no homology to known proteins other or signal peptide sequence motifs mammal or human.

Lack of significant homology with other proteins complicates the efforts to elucidate the function of Menin. Carcinogenic tumor suppressor gene MEN1 should Knudson (30) “two hit” model. The first hit was a MEN1 germline mutation heterojunction that are present in all cells at birth has been developed at an early stage embryo, or inherited from the (family problems) one parent and (sporadic) . Usually MEN1 somatic mutations that occur in predisposed endocrine cells as a loss of the wild-type allele remaining to allow cell survival required for tumor development, second hit is large deletions. Mutations in the MEN1 gene can be identified by 95% from 70 to about 20% of the pocket hyperparathyroidism of patients and families MEN1. All patients were heterozygous for the mutation almost. The family affected, individuals homozygous, and are identified by MEN1 mutations heterojunction. In this family, there was no difference in the history of the heterojunction between carriers and homozygous mutations.

To develop the signs and symptoms of 20-year-old, more than 95% have symptoms of 40 years 50% of patients. Onset, severity of disease, and considerably within and there is variation between families in the era of tumor type. In spite of many studies, it means that is included in the phenotypic expression of MEN1, environmental modifiers genetic factors and unknown were identified correlation of the genotype and phenotype. Under type 1 multiple endocrine tumors (MEN1), a rare hereditary endocrine cancer syndrome, which is characterized by (95% of cases) tumor of the parathyroid mainly, and (80% from 30 cases) endocrine gastrointestinal (GEP) tube (15-90% of cases) is a pituitary anterior lobe. Lipoma of the skin non-endocrine cancer endocrine and other tumors, including thyroid and adrenal cortex, and internal organs, meningioma, and bronchial carcinoid and thymus collagenomas of facial angiofibromas, and stomach, may also occur. Phenotype of MEN1 is wide, the combination of more than 20 kinds of non-endocrine activity and endocrine is described. MEN1 should be suspected in patients with endocrine disorders 2 of the first level to the MEN1 syndrome who underwent target organ characteristic of the three, the positive impact of any of these agencies or endocrine disorders,.

MEN1 patients have a family history of MEN1 usually. Inheritance, has a 50% chance to send a disease to offspring of their parents autosomal dominant, have been affected. MEN1 gene mutations may be identified in MEN1 70 ~ 95% patients. While associated with an increased risk of malignant tumors, MEN1 other tumors is MEN1 cause and symptoms of benign excess of local action and table hormone endocrine tumor of many. About one-third of patients affected by MEN1 die earlier than MEN1 associated with cancer or malignant related. Thymus and intestine pancreatic gastrinoma, bronchial carcinoid is a major cause of morbidity and mortality. Thus, (55.4 years 46.8 years for men and women) average age of death of people with MEN1 significantly lower than the general population.