|Product name||Prostate adenocarcinoma|
|No. of samples||1|
Age/Sex : 59/M
Product Related Literature
Gleason grading system was to evaluate the prognosis of men with prostate cancer. Incorporated strategies prostate cancer stage helps to predict the other parameters, the estimated values together, to guide the treatment. Gleason score is given to the prostate based on its microscopic appearance. Cancer is more aggressive and high Gleason score, it is a poor prognosis. In most cases, radiologists and urologists, through the rectum using a biomedical scientist in the laboratory histology prepared microscope slides for immunohistochemistry for diagnosis by pathologists and H & E and needle, a hollow I remove a cylindrical sample of prostate tissue and (biopsy). Prostate, after being removed during surgery, a pathologist will slice the prostate for inspection.
The pathologist is assigned a Gleason score based on the sum of the two numbers. It is a rank of tumor models the most common, is the second number, the first number is the degree of the most common model of second. If the model of three of the first number is present, the most common and, second, is the highest class. For example, tumor model is the most common third degree, but it will be some cells is a fourth grader has been found, Gleason score 3 + 4 = 7. The second number, which is a slight change in the Gleason system pre-2005 is the level of the secondary cell lines most common. This class also known as Gleason pattern, or Gleason score, and is known as a sum Gleason. With the prognosis of five worst Gleason pattern and Gleason grade in the range of 1 to 5. Gleason score is in the range of 2 to 10, 10 to the worst prognosis. Cancer more aggressive Gleason 4 +3 and evaluation of Gleason 7 3 +4 Gleason. In addition, there is no really difference between the tumor or 10 attack assessment Gleason 9.
Then, in order to obtain a final result, these materials are added grease. Increasingly, pathologist, to provide evidence of “high” component. Where just a few of the 1 (Normal attack) model of 3 minutes. Therefore, there may be 3 +4 tertiary Gleason parts of the scheme to make it 5 – would be considered it, and prostate cancer more aggressive in Gleason 3 +4 5 without high-end models. Although it is a question as a certain degree of any full component highly malignant cancer. I have never seen almost 2 in the form of current, system Gleason, and prostate cancer Gleason pattern 1, and Is the rarely seen and live by definition. Gleason pattern 3 is the most common by far. So 3 +3 = 6 Gleason score, it is considered as a class of cancer can be seen in practice, usually, these cancers should have a pretty good estimate actually.
The scoring system, named pathologist in the development Minneapolis Veterans Affairs hospital is equipped with colleagues at other facilities in this Donaldson, in 1960. In 2005 from the international community of urinary pathology, Gleason, change the system. The sophisticated, standards, has changed the decision of some models. Incidentally, has a higher performance compared to the original Gleason score modified “above, it standard that is acceptable to the urological pathology current has been demonstrated. In this form, it remains important tools some.
Prostate cancer is a form of glandular cancer onset, of the male reproductive system in the prostate. Growth is slow prostate most cancers, but in some cases of invasive cancer of the prostate. Tumor cells can be from prostate other body parts, especially in lymph nodes and bone to (spread) transition. Prostate cancer, the problem may be pain, difficulty urinating, during intercourse, or cause erectile dysfunction. Other symptoms, may occur during the later stages of the disease potentially.
Is detected less frequently than South Asia, East Asia, in Europe, in the United States, detection rate of prostate cancer varies greatly throughout the world especially. Prostate cancer tends to develop in men over the age of 50. Globally, (currently, the first of the second in the United Kingdom and the United States) it is a major cause of the sixth of cancer-related death in men. Prostate cancer is most common in developed countries has increased in developing countries. However, many men, not treated without symptoms never, prostate cancer die because of other unrelated eventually. Many factors, including the Food and genetic is involved in the development of prostate cancer.
It can be shown by biopsy presence of prostate cancer, symptoms, physical examination, prostate specific antigen or (PSA),. The prostate-specific antigen test, detection of cancer will increase, but it does not reduce the death rate. Because of the risk of retreatment and overdiagnosis, such as prostate cancer, U.S. Preventive Services Task Force will remain asymptomatic, which is recommended for screening for prostate cancer using the test PSA in 2012. USPSTF concluded that the potential benefits of the test is not exceeded expectations harm.
Management strategy for prostate cancer, should be guided by the severity of the disease. I can be low-risk tumor to track active surveillance very safely. For curative treatment, typically do not include surgery according to radiotherapy and various normal or cases of advanced disease rarely more, cryosurgery, hormone therapy, chemotherapy, and the (hormonal therapy Regardless, in some cases, it is reserved for applying a radiation of) possible. Several studies, masturbation, has been shown to reduce the risk of prostate cancer.
About human age, and health, of metastasis, appearance, and the base of the response of the cancer to initial treatment are important in determining the prognosis of the disease under the microscope. Decision of whether to treat (cancer contained in the prostate) localized prostate cancer patients and radical is a compromise between the adverse effects to the expected beneficial to survival and quality of life of patients.
Usually do not cause symptoms early prostate cancer. But sometimes, the symptoms are similar to these diseases as benign prostatic hyperplasia such frequent prostate cancer. These include (painful urination) dysuria to start the steady stream (nocturia) frequent urination frequent urination at night, difficulty urine, maintain, and, hematuria (blood in the urine) is included . About one-third of patients diagnosed with prostate cancer between asymptomatic, two-thirds have more than one of these symptoms.
Prostate cancer is associated with dysuria prostate that surrounds the prostatic urethra. Therefore, changes in the gland can affect the urinary function directly. Secretion of the prostate and seminal of the urethra vas deferens deposits prostate as included in the content semen, prostate cancer, it’s performance sexual function and as difficult to obtain ejaculation and painful erection of such can cause problems.
Advanced prostate cancer, which can cause additional symptoms probably spread to other parts of the body. In many cases, (bones of the spine) spine, ribs and pelvis, the most common symptom is bone pain. Toward the proximal portion of the bone, cancer, spread to the bone of others, such as the femur in general. Prostate cancer of the spine, can be pressure and weakness of the legs, leading to fecal incontinence and urine, and spinal cord.