|Product name||Lung cancer-metastasis-normal|
|No. of samples||59|
|No. of patients||40|
|Core diameter||2.0 mm|
|Section thickness||4 micrometer|
Product Related Literature
It is similar to many other types of lung metastatic cancer, lung cancer is initiated by activation of inactivation of tumor suppressor genes or oncogenes. It is believed that people cancer gene, cancer and the more susceptible. I have considered proto-oncogene and become cancerous gene when exposed to carcinogenic substances. Mutations in proto-oncogene of K-RAS is responsible for 10-30% of lung adenocarcinoma. Epidermal growth factor (EGFR), which regulates cell proliferation, apoptosis, and tumor invasion and angiogenesis. Amplification and mutation of the EGFR is common in non-small cell lung cancer, and provide the basis for treatment with EGFR inhibitors. The HER2/neu is affected too much. Chromosome damage, can lead to loss of heterozygosity. This can lead to inactivation of tumor suppressor genes. Staining 3P, 5q is particularly common in small cell lung cancer is damage to the 17p and, of 13q. P53 tumor suppressor gene in the chromosome 17P on, is affected by the 75 percent of cases from 60. Is amplified or mutated frequently, c-MET, NKX2-1, LKB1, PIK3CA, and other genes, is BRAF.
When you do a chest X-ray examination, it is the first step to investigate if the symptoms a person suggest the lung cancer has been reported. This can be (suggesting spread to lymph nodes there) mediastinum, to clarify the expansion of pleural effusion atelectasis (collapse), or integrated (pneumonia), an obvious mass. Typically, CT imaging can be used to provide more information about the type and extent of disease. CT-guided biopsy or bronchoscopy is used to take a sample of the tumor for histopathological examination often.
In many cases, lung cancer can appear as solitary pulmonary nodule of the chest X-ray photo. However, differential diagnosis is wide. You can include organizing pneumonia tuberculosis, fungal infection, or metastatic cancer, to give something like this also, disease and many others. Common cause less solitary pulmonary nodule include hamartoma, bronchial cyst, adenoma, arteriovenous malformation, pulmonary sequestration, rheumatoid nodule, the lymphoma and Wegener’s granulomatosis. Lung cancer can be as lung nodules single CT scan or on X-ray that was done for reasons unrelated breast, to discover at random. Definitive diagnosis of lung cancer is based on histological examination of suspicious tissue in the context of the radiological features and clinical.
It is classified according to the lung histological type. This classification is important in determining the prognosis and management of the disease outcome. The majority of lung cancer is a cancer arising from epithelial cells. Lung cancer is classified by the type and size of the observed cancer cells under a microscope from histopathologist. Two classes are small cell lung cancer and small cell.
Adenocarcinoma, squamous cell lung cancer, a major three subtypes of NSCLC is a large cell lung cancer. About 40% of lung cancer, are originating from peripheral lung tissue usually. Most cases of adenocarcinoma associated with smoking, among those who smoked less than 100 in the life of (“smokers never”), adenocarcinoma is the most common form of lung cancer. Subtypes of bronchioloalveolar adenocarcinoma, the woman who does not have a never smoker is common, there may be long-term survival excellent. Squamous cell carcinoma, accounting for about 30% of the lung. They usually occur in the vicinity of large airway. The cavity associated with cell death, often, I can be found in the center of the tumor. About 9% of the lung is large cell carcinoma. Cancer cells is large, in the black of visible nucleolus great quality and very, are named them.
When you stage a lung cancer, it is the evaluation of the degree of spread of cancer from its original source. This is one of the factors that can affect the potential treatment of lung cancer and prediction. Initial evaluation non-small cell lung cancer using the TNM staging classification (NSCLC). The size of the primary tumor, lymph nodes and this is based on the involvement of distant metastases. Then, using the TNM descriptor 0 through stage one group begins cancers feces are determined and IV IA (A-), IB, IIA, IIB, IIIA, and IIIB.
In this step, I will assist the band selection of the evaluation of prognosis and treatment. Are classified small cell lung cancer “period”, the (SCLC) traditional (not limited to half of the breast, allowable radiation field) “rich stage” or as (widespread disease). However, grouping and TNM classification are useful for evaluating the prognosis. Case of SCLC and NSCLC, clinical stage, the main types of braking score 2, has been staging surgery. Clinical stage is carried out before the final operation. The image inspection (for example, PET scan and CT scan), are based on the results of the biopsy. Is evaluated after surgery or during surgical staging is based on the combined results of clinical data and includes a surgical sample of thoracic lymph nodes.