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In addition, peptic ulcer, also known as peptic ulcer disease, so acidic in general, is the most common areas of ulceration of the gastrointestinal tract is very painful. It is defined so that it can be exacerbated or caused by drugs aspirin, such as 0.5 cm ulcers, and nonsteroidal anti-inflammatory drugs and other ibuprofen erosions or equal to mucosa.
Peptic ulcer of many, the first part of the small intestine to the stomach itself as occurs four times in the duodenum, and, following the stomach immediately. About 4% of the ulcer since caused by malignant tumors, biopsy plurality are needed to exclude cancer. Ulcer, benign in general.

The history of the use of a particular form of drug heartburn, gastroesophageal reflux disease and (GERD), you may occur due to suspected peptic ulcer. Includes inhibition of NSAIDs (non-steroidal anti-inflammatory drugs) glucocorticoids (eg, dexamethasone and prednisolone) and cyclooxygenase the most drugs that are associated with peptic ulcer.
Two weeks or more, in patients with 45 or more people you have the above symptoms, the odds of peptic ulcers, high enough to justify the investigation rapid esophageal stomach.

The timing of the symptoms associated with feeding, there is a distinction between duodenal ulcer and stomach. Gastric ulcer would give epigastric pain during a meal of gastric acid production to increase food enters the stomach. By symptoms of duodenum is released from semolina, such as pyloric sphincter like the first, the acid, it does not reach the duodenum Close the focus of the contents of the stomach. When the stomach began to release the acid digestion and food into the duodenum, after 2-3 hours meal, pain of duodenal ulcer occurs mainly. It is also possible symptoms of peptic ulcer is varied depending on the age of the patient and the location of the ulcer. However, there is a tendency for ulcers typically is processed is repeated, there can occur a few days or weeks pain obtained is decreased or disappeared thereafter. Unless complications occur, children and the elderly do not develop symptoms usually.

Duration or baked in the abdomen during 30 minutes, 3 hours, gnawing sense that involves the ulcer in general. This pain hunger, it can be mistaken for indigestion or heartburn. Usually, pain caused by ulcers, but can be affected by gastric acid when in contact with the ulcer area it. There will be worse may can feel the navel sternum nowhere pain due to peptic ulcer, it takes minutes to hours, the stomach is empty. Further, it is possible pain becomes active at night sometimes, often can be alleviated by by eating the foods buffer gastric acid or temporarily adopt an anti-acid drugs. However, symptoms of peptic ulcer disease, may be different for each patient.

It is a chronic inflammation (~ 60% 90% of duodenal ulcers and in the stomach) major factors due to Helicobacter pylori, it colonized the antral mucosa. Despite not be able to clear the infection, [8] the immune system, the generation of antibodies. Thus, the resulting defects in the regulation of the production of gastrin in this part of the gastric secretion of gastrin, comprising (type B gastritis) chronic active gastritis, or has, as in most cases, bacteria increases, may result in hypo-achlorhydria, I will be reduced or even. Gastrin stimulates the production of stomach acid by the parietal cells. In order to increase the gastrin H. pylori colonization responses acid increased, may mucosa for, which contributes to a reduction in ulcer formation. The study ulcer various Third World countries, despite the high price pylori colonization N. display nutritional factors play a role in the pathogenesis of the disease.

Another important reason is the use of non-steroidal anti-inflammatory drugs. Be protected from gastric acid by a layer of mucus secretion is stimulated gastric mucosa, by prostaglandin specific. NSAID blocks the function which is essential for the production of prostaglandins these cyclooxygenase-1 (COX-1). Inhibit importance in the gastric mucosa is reduced which is on a priority basis (such as withdrawn rofecoxib or celecoxib), halve the risk of NSAID-related gastric ulcer abbreviation, the COX-2 COX-2 selective anti-inflammatory agents.

The incidence of duodenal ulcers decreased significantly over the past 30 years, the incidence of gastric ulcer showed a slight increase caused by the spread of non-steroidal anti-inflammatory drugs mainly. I considered regardless of the decrease in frequency, progress of treatment of this disease, and is a group occurs. Cohort phenomenon, H. pylori reduces the incidence of infection H. perhaps, be explained by the improvement in living standards.

In some studies, and found a correlation between ulceration and smoke, but the search risks are more specific, unless it is associated with infection with H. pylori, others by itself Smoking has been found that it may not be a lot of risk factors. Some of the risk factors that have been proposed as a spice consumption and diet, it is assumed to (help the cause ulcers) ulcerogens up to the end of the 20th century, but the development of peptic ulcer is less important relatively shown are. Further, coffee and caffeine believed ulcers may occur generally worsen, can affect the ulcer significantly not known. Increasing the risks associated with H. pylori infection has been shown that the consumption of alcohol, but does not appear to independently increase the risk, similar study is a case coupled with H. pylori infection also, modest increase factor is related to the main risk.