|Product name||Various cancers, high density (2)|
|No. of samples||146|
|No. of patients||146|
|Core diameter||2.0 mm|
|Section thickness||4 micrometer|
Product Related Literature
Any ionizing radiation in 11% of invasive cancer, associated with exposure to radiation, including non-ionizing radiation. Furthermore, the cancer is non-invasive, many are non-melanoma skin cancers caused by non-ionizing UV radiation. Position of the UV on the electromagnetic spectrum, a boundary between the non-ionizing radiation and ionization. Mobile phone, power transmission, and non-ionic radio frequency radiation from a source other similar international organizations for Research on Cancer of the World Health Organization has been described as a possible carcinogen, but the relationship is unclear.
Exposure to ionizing radiation, increasing the incidence of future leukemia, cancer in particular are known. mechanism this occurs is well understood, but quantitative models for predicting the level of risk, is controversial. Cancer caused by radiation most widely accepted assumptions the model to increase linearly with the effective dose rate of 5.5% per sievert. Linear model is correct, is the source most dangerous of radiation to the public health medical imaging follow as second close to natural background radiation then.
Cancer increased the effective dose of radiation probability, but the severity of the cancer is the stochastic effects of radiation which means that there is no dose-dependent. Progress of the characteristics of any other disease and the degree, cancer, prognosis, pain, speed was not a function of the radiation dose a person is exposed. This increase in severity and dose exceeding the threshold contrast to deterministic effects of the acute radiation syndrome. A single cell in which the function is impaired, Cancer begins. Operation called chromosomes in normal cells is controlled by the chemical structure of DNA molecules.
When depositing sufficient energy to the tissue to cause ionization, so destroying the molecular bonds tend to alter the molecular structure of the molecules are irradiated radiation. Not only cause excitation ionization, usually, radiation and energetic little visible light, etc., is dissipated as heat in the relatively small chemical damage. The ultraviolet light, typically, is classified as non-ionic, it is an intermediate region that produces a chemical damage and ionization few. Therefore carcinogenic mechanism of the UV radiation is the same as that of ionizing radiation.
In contrast to trigger cancer chemical or physical, I pass through the radiation hits molecules in the cell at random. Destruction molecule can be a highly reactive free radicals cause further chemical damage radiation. Some cost direct and indirect These factors affecting epigenetic controls the expression of a chromosomal gene in the end. Mechanism of the cells, to repair some of this damage, but the repair of some is not accurate, and chromosomal abnormalities some will prove irreversible.
DNA double-strand breaks are the (DSB), that that ionizing radiation can cause cancer in general, it is important lesion biologically most are accepted. Experiments on in vitro shows an aliquot of the marker epigenetic DNA that control gene expression, 35 DSB to ionizing radiation causes DSB’s and Serugure. Most of the DSB induced be repaired within 24 hours after exposure, but within four days after exposure to be repaired 25% of the fiber is repaired improperly, about 20% of the fibroblasts exposed 200mGy I died. Some of the population because it has a disadvantage in DNA repair mechanisms, and suffer many injuries due to exposure to radiation.
It is not possible to reproduce the main damage, and lead to cell death normal. This effect is the cause of the acute radiation syndrome, damaged cells big these will be able to become cancerous. In particular, if a state of proliferation when tumor suppressor genes are damaged, damage heavery is able to leave to develop into cancer eventually becomes stable, the cellular functional partially You. In the latest study, I show that the events of mutagenicity does not occur immediately after irradiation. I suspect Instead, the genomic instability that causes an increase in the mutation frequency in future generations of viable cells is obtained. Cell will progress through malignant transformation, the multiple stage of may result in tumor after years of incubation. It can be divided into three stages mainly malignant transformation: Get Device immortal cells and promote the formation of tumors, morphological changes independent cell.
In some cases, low doses of radiation may be after radiation, to mitigate the effects of high doses. This is known as “adaptive response” and is associated with the hypothetical mechanisms of hormesis. Incubation period of several decades, can be elapsed between the detection of cancer and radiation exposure. Cancer of these can be developed as a result of exposure to radiation, can not be distinguished from those that exist as a result of exposure to carcinogens or other, in nature. In addition, the literature of the United States National Cancer Institute, indicates that the hazards and chemical and physical, smoking, alcohol consumption, and lifestyle factors such as diet contributes greatly to many of the same disease of these have. Data from uranium miners, suggesting that rather than multiplication of smoking, and radiation, it is the interaction with the additive. Estimate of the contribution of radiation to cancer incidence, can be done by epidemiological extensive research with in-depth data for other risk factors of all.