|Product name||Uterus endometrial adenocarcinoma|
|No. of samples||1|
|Description||uterus, endometrial adenocarcinoma
Age/Sex : 34/F
Product Related Literature
Endometrial cancer affects the various types of malignant tumors result from the mucous membrane of the uterus or endometrium. Women and more than 35,000 have been diagnosed each year, endometrial cancer is the gynecological cancer most common in the United States. Frequency has increased the secondary epidemic of obesity gradually. Are related occurrence obesity in the determination of endometrial hyperplasia can occur within decades of normal menopause, the more estrogen and excessive exposure, sub-the most common type, endometrioid adenocarcinoma, from the vagina It is located in the most frequently bleeding. Endometrial cancer is the third most common cause of (behind the cervical cancer and ovarian) gynecological cancer death. Hysterectomy total abdominal and bilateral salpingo-oophorectomy, is the most common treatment. Endometrial cancer, may be referred to as uterine cancer sometimes. However, other cancers may be not only from the endometrium within comprises myometrium cervical cancer, sarcoma, and trophoblastic disease, is formed as well as other tissues of the uterus.
Endometrial cancer most, indicates that you are from a single layer of epithelial cells, in the form of endometrial glands and line the endometrium, cancer they are (usually adenocarcinoma). And inner membrane common type growing in a pattern reminiscent of normal endometrium, cancer cells endometrial cancer, including clear cell carcinoma of the endometrium and aggressive papillary serous cancer much There is a sub-type of microscope many. Endometrial cancer were classified into two categories based on the pathogenesis and clinical features. In many cases, thickening of the (endometrial hyperplasia) lining of the uterus excessive, and post-menopausal women and the surrounding before they occur most often, the type of first in, the exposure to high levels of estrogen with a history of, these inputs are not neutralized by (unopposed estrogen exposure) progesterone endometrial cancer I am more often in the Caucasian population. When you enter the endometrial cancer, is a minimally invasive uterine wall basic things of poor quality. Many (myometrium) is the inner membrane type, I carry a good prognosis.
The second type, endometrial cancer of type II, is the most common in the elderly, in postmenopausal women, those of African-American people are common, and is associated with the exposure of the increase in estrogen does not have. And invasion, clear type or serous uterine cancer, in many cases, is a high-grade endometrial cancer of Type II, with a poor prognosis deep into the uterine wall underlying the (myometrium) have.
FIGO classification of endometrial cancer. The histopathological examination of endometrial cancer, it is very diverse. Observation most common are peeling adenocarcinoma, endometrioid, and mitotic activity, is composed of many small, in active glands at different levels of well-differentiated nuclear atypia. In many cases, this is done in the background of endometrial hyperplasia. Frank adenocarcinoma may be distinguished from atypical hyperplasia represents a non-destructive replacement of endometrial stromal or cancer findings, the clear interstitial infiltration by the “back-to-back” glands. As the disease progresses, instilling in the myometrium. However, subtypes of endometrial cancer other, and there is an unfavorable diagnosis, such as clear cell carcinoma and serous papillary carcinoma of the uterus.
This is a low yield, cancer patients newly diagnosed endometrium is not performed, the images such as CT scan, such as to assess the extent of the disease. Including liver function tests, physical examination and complete medical history, rectal examination and stool guaiac test and pelvic examination, chest X-ray, complete blood count and preoperative evaluation should include a blood chemistry test. Stool is recommended colonoscopy if you have symptoms etiology factors positive woman or guaiacol is common to colon cancer and endometrial cancer. It is possible to predict an advanced stage, sometimes tumor marker CA-125 is checked. In addition, D & C, and Pipelle search curettage give a positive predictive value to 70 65%. However, the most important of these is the uterus, which gives 90-95% positive predictive value.
The main treatment is surgery. Surgical treatment, there exploration ascites, the abdomen, the lymph node suspicious biopsy and palpation, should consist of specimen and cytology at least of (bilateral salpingo-oophorectomy) removal of both ovaries and abdominal hysterectomy. Para-aortic lymph nodes and pelvis, removal of invasion of more than 1/2 of the myometrium more done for tumors have lymph node dissection, the characteristics of high risk, such as clear cell and tumor pathological grade 3 serous sometimes , or extension of the neck or appendages. Removal of the network is carried out sometimes.
It, so you can check the cleaning solution of the abdominal cavity in order to detect further evidence of cancer, to get, abdominal hysterectomy is recommended vaginal hysterectomy. Women with stage of stage 1 are at risk of high people with stage 2 disease and recurrence, offers surgery in combination with radiation therapy often. For those having four or disease stage 3 in particular, chemotherapy may be considered in some cases. Hormone therapy with progestogen and anti-estrogen, is used for the treatment of endometrial stromal sarcoma. Antibody Herceptin is used to treat the breast cancer overexpression protein HER2/neu can test some success in phase II trials in women with the uterine papillary serous carcinoma overexpression of HER2/neu will be.