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Possibility of rejection to be reduced, tissue matching, say that it matches the type of organization of the donor and recipient for tissue transplantation or organ transplantation. Histology individual dependent and is displayed on the cell surface, the specific molecules called human leukocyte antigen (HLAS). In HLA-A, the HLAS three basic known as HLA-DR and HLA-B. Antigen is a protein encoded by the gene of the main histocompatibility complex on chromosome 6.

There HLA gene, which means a lot of different variants of each antigen present in the human population, the number of polymorphisms between. HLA-, of the practice of any specific and HLA-DR HLA-B There are more variants of known 50 of 100. Some embodiments are more common than others. Since two copies of one chromosome 6, it is possible to produce different versions of the two HLA. Therefore, fabric found to match exactly – 6 – antigen match – that between individuals completely unrelated two is very difficult.

Fortunately, there is a tendency to give the HLAS of these, therefore, they are related to tissue type since the same gene family. This is much easier to be able to get the matching of tissues and organs of the family from non-relative. Antigen is rare or common in the general population a chance to find a matching fabric of family, the difference of two families is related depends on whether it is something. Because it inherits a copy of the sixth chromosome from each parent, the children, have a mixture of antigen of the parent. If the HLA gene are mixed at random from each parent, the child of two people of any small probability (<1%) there are so be of the same type of organization.

However, HLA three genes on the chromosome of each come together in one place, they tend to be inherited as a block chance of siblings that share the same tissue type them, it is one in four. By examining the direct DNA sequence in the main histocompatibility complex or, by specific test HLAS of serum samples, transplant physician or graft before you determine the type of organization of the donor and recipient. Rejection, six antigen match is not always necessary to be able to be overcome by the use of immunosuppressive drugs. However, when exposed to one or more of HLAS (as may be the result of a blood transfusion before) donor already may have antibodies that already exists, the receiver rejects it I increase the likelihood of the reaction. This is comprising by mixing a part of the donor cell and the recipient’s serum was tested by cross-matching. There is a possibility that the negative transplant will be successful if there is a cross-match test.

Before porting the organization of the donor and recipient potential, tissue typing is a procedure that has been tested for compatibility. Embryo may be tissue typed in order to ensure that it is possible to donor stem cells in cord blood relative of the disease embryos. The lymphocytes from the donor, a technology of tissue types is performed by culturing with those of the recipient as “mixed leukocyte reaction”. It is known as micro-cytotoxicity assay using sera and anti-HLA antibody known to recognize (HLA-A, HLA-B, HLA-C, HLA-DP, HLA-DQ, HLA-DR) the inner HLA gene to deal with individuals who are similar genetically in the hope other techniques, to make the transplanted tissue. Donor cells are posted from mixing with anti-HLA antibodies, including the MHC serum in this technology. After complement activation occurs, antibodies, when recognizing an epitope of the ICC on the permeation cell is dissolved. Cell lysis result in the receipt of dye (trypan blue). This enables the identification of cells of MHC indirectly on the basis of the specificity of the antibody known in the serum.

human leukocyte antigen one of the tools used by the body to fight invading foreign matter is a (HLA). HLA is composed of proteins that regulate how the body recognizes a foreign body. The reception of the HLA-sensitive organ, the patient has developed antibodies to the HLA of potential donors. If you need to carry out transplantation of HLA compatibility, the recipient’s immune system will attack the HLA-bearing cells in the donor organ. This causes the transplanted organ to fail. People can become sensitized by exposure to foreign matter. When they are exposed to the external fabric of the blood and previous organ transplant or her unborn child, can occur during pregnancy this woman.