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Thrombus or blood clot, is the final product stage of coagulation hemostasis. This is achieved by aggregation of platelets to form a platelet plug, activates the body fluids coagulation system. Usually, thrombosis is the case of injury, but are cases of thrombosis pathological. Thrombus is attached to the vessel wall mural thrombus. Rather than obstructive, they affect the great vessels such as the aorta and heart. Represents a group of fibrin and red blood cells and white blood cells woven significantly, they appear red gray alternating dark and bright line part.

Specifically, thrombus is inappropriate activation of the hemostatic process of minor injuries or vessel health. Thrombi large blood vessel, reducing blood flow through the vessel. It is not possible in a small blood vessel, to cut off leading to the death of tissue blood flow is supplied by the blood vessels completely. Dislodges, as it is called embolization, thrombus In the event of a suspension. Some of the conditions that increase the risk of developing blood clots, atrial fibrillation, heart valve replacement, are related to the lack of clotting ability of blood and genetic disorders and period, long heart attack, the non-active recently.

I reduce the risk prevention and treatment of blood clots, stroke, heart attack, pulmonary embolism. Is used to inhibit the formation and development of blood clots existing often bind to the former, heparin and warfarin, enzyme inhibition vitamin K epoxide reductase second, while enzyme required for synthesis of clotting factors mature inhibitor, activates anti-thrombin III. Several treatments are prepared from bacteria. Streptokinase is a drug is an enzyme secreted by Streptococcus some bacteria. This drug can be used to dissolve the coronary vascular thrombosis, which is administered intravenously. However, streptokinase is a non-specific, I can can lead to secondary problems of many to take advantage of the protein virtually any. Run faster than the other thrombolytic, and more concretely, the enzyme called (tPA) tissue plasminogen activator. The drug is dissolved plasminogen thrombus converting enzyme plasmin prepared from transgenic bacteria. There is also a anti-coagulant some that comes from animal work by dissolving the fibrin. For example, Haementeria ghilianii produces an enzyme called salivary glands hementin of his reach to Amazon. Since 2012, this enzyme is produced by normal genetically engineered bacteria is administered to the patient in the heart.

In a multicenter randomized trial of recently compared the (CDT) standard catheter-induced thrombolysis in Inc. (USAT, of ekos) ultrasonic acceleration of thrombus for the treatment of acute peripheral arterial occlusive thrombus. The results, on average, patients treated with USAT show that the finished than those processed without an increase in the standard of CDT 12 hours prior “to serious adverse events.” Plan is to start become a non-randomized trial of a system of lower hourly rate ekos dose of the drug with the hope that reduce bleeding complications and further study of DUET II.

Disseminated intravascular coagulation (DIC) includes a micro-thrombus formation widely in most of the blood vessels. This is fibrinolysis with platelet of all available blood clotting factors body and clotting factors, due to excessive consumption of subsequent activation. The end result, it Is the ischemic necrosis of tissue / organ or bleeding. Sepsis, acute leukemia, shock, snake bites, why is a fat embolism from serious injuries and other fractures. DIC is seen in pregnant women. Further, in order to prevent the formation of thrombus, the treatment involves the use of fresh frozen plasma to restore the level of clotting factors with heparin and platelets. Usually, and aortic aneurysm or injury of atherosclerotic aortic wall, thoracic aortic thrombosis is a rare pathology derived from a potential source of peripheral embolization and visceral brain.

Thrombus, can have one of four results. Recanalization propagation, embolization, dissolution, and organization. Prevalence of thrombus occurs towards the direction of the heart. This means that the retrograde or antegrade vein to the artery. embolism occurs when a blood clot is released from the blood vessel wall, it became mobile phone. (Most likely from deep vein thrombosis of the lower limbs), as a result of travel pulmonary embolism, venous emboli reach the right side of the heart and travel through the pulmonary artery to the systemic circulation. While due to atherosclerosis, the artery thrombosis, well, the embolism, you may want to block the artery downstream of thrombus formation or artery, respectively, as a result, even a mobile phone or hypertension,. This can lead to other body stroke, myocardial infarction or unit, is affected.
Dissolution occurs when it is returned to the container fibrinolysis mechanism to break the flow of blood and thrombus. This may be an auxiliary agent (e.g., after occlusion of the coronary artery) by. Best response of fibrinolytic drugs is within a few hours it is fully developed in fibrin network of blood clots before.

Recanalization and organization includes the internal growth of endothelium in thrombosis rich fibrin smooth muscle cells, and fibroblasts. If you proceed recanalization, it provides the capillary channel and thrombus large for the continuity of blood flow through the thrombus overall, but there are times when it does not recover enough blood flow to the needs of the tissue metabolism of downstream .