Esophagus squmous cell carcinoma

Product name Esophagus squmous
Cat. No. 6280523A
No. of samples 1
Description esophagus, squmous
Age/Sex : 52/M
Price 197 EUR
260 USD
170 GBP

Esophagus squmous cell carcinoma

Product Related Literature

Barrett’s esophagus (British English: Barrett’s esophagus), or, called Barrett’s columnar epithelium sometimes the bottom of the esophagus (CELLO) are lined up, but I refers to deviation in the cells of the lower esophagus (metaplasia). In the case to be replaced in (found in the lower digestive tract cells usually) normal squamous epithelium goblet cells in the mucous membrane of the esophagus, has been diagnosed with Barrett’s esophagus. Medical significance of Barrett’s esophagus is a powerful relationship esophageal adenocarcinoma, a cancer of a particularly deadly.

The main cause of Barrett’s esophagus is believed to adapt to acid chronic exposure of GERD. During the last four years, the incidence of esophageal cancer is increasing in the Western world. Is a large subset of Barrett’s esophagus patients have symptoms, but Barrett’s esophagus occurs in 5-15% of patients seeking medical care for heartburn. It is considered a precancerous condition (especially adenocarcinoma) as it is associated with an increased risk of cancer to about 0.5% of patients per year. If the cancer has developed, it is often fatal. Diagnosis of Barrett’s esophagus, which require biopsy (specifically, esophagogastroduodenoscopy, fiber optic cables, the procedure in order to examine the duodenum esophagus, and stomach, is inserted through the mouth) and endoscopy. Cells of Barrett’s esophagus was classified into four categories mainly after biopsy: frank cancer dysplasia non-dysplasia, low-grade, and high-grade dysplasia,. The adenocarcinoma and high-grade dysplasia early, endoscope, such as radiofrequency ablation and advanced (mucosa) is treated by new treatment endoscopic resection for recommend that kick usually receive surgery I can. The high-grade dysplasia that is recommended that usually, in the radiofrequency ablation as an option for treatment, subject to surveillance endoscopy of the annual risk of developing cancer, low patients with non-dysplasia, the patient’s It may be years or 10%.

Barrett’s esophagus is due to chronic inflammation. Gastroesophageal reflux, GERD major cause of chronic inflammation is: (GORD UK). In this disease, I cause damage to the cells of the esophagus content of heartburn pancreas, gallbladder, and small intestine, is low. Recently, inhibition of the receptor protein kinase Akt epidermal growth factor receptor and (EGFR) [7], it is possible to induce differentiation intestine cells gastroesophageal junction has been shown to bile acids. This is the final activation of the homeobox gene CDX2, which is responsible for expression of the enzyme guanylate cyclase intestinal such as 2C and up-regulation, of the sub-unit of the p50 protein complex NF-κB of (NFKB1) finally I bring. This mechanism, also known (as of ErbB2 selection process of HER2/neu (effectiveness and carcinogenicity of targeted therapy for HER-2 receptor trastuzumab in the treatment of gastroesophageal junction adenocarcinoma and (Herceptin) Description GEJ.

Researchers can not be used to predict patients with acid Do you want to develop Barrett’s esophagus. But there is no relationship between the link between the development of Barrett’s esophagus and weight, of acid, the development of Barrett’s esophagus and chronic acid. Sometimes, you do not have symptoms of heartburn People with Barrett’s esophagus. In rare cases, for example, damage to the esophagus may be caused by the ingestion of corrosive substances such as alkaline solution.

The results microscopic and positive (endoscopic) macroscopic Both are required to make the diagnosis. Barrett’s esophagus is characterized by the presence of columnar epithelium in the lower part of the esophagus squamous normal cells, at the site of an example of metaplasia. It is possible to withstand the erosion stomach glands, metaplasia of the columnar epithelium secretion is good, but may provide an increased risk of adenocarcinoma this.

The presence of cell cup called intestinal metaplasia, it is necessary to make the diagnosis of Barrett’s esophagus it. This often occurs in the presence of a column of metaplastic cells other, but only the presence of goblet cells is diagnostic. Epithelium of Barrett’s esophagus are visible with the naked eye through the stomach, but biopsy to examine under the microscope for cells to determine whether it is the stomach and large intestine in the wild. Colonic epithelial metaplasia, typically are identified by finding the goblet cells, it is necessary for the actual diagnosis of Barrett. Goblet cells are generated in the transitional epithelium of the normal esophageal submucosal glands (ie, there is a histological many imitators Barrett’s esophagus Mucin type rich pits a “cell Pseudogoblet” to simulate the goblet cells of acid mucin true).

That submucosal glands and to evaluate the relationship of transitional cell type in consideration of the several levels of organization within the distinction between (a special columnar metaplasia) submucosal glands true Barrett’s esophagus and goblet cells ensures that the pathologist makes it possible to. Using the 2.5 Alcian blue histochemical staining solution pH, and is used to distinguish the genuine type intestinal mucin by mimicking the tissue of their frequently. Recently, immunohistochemical analysis is used to identify the type of intestinal metaplasia actual cells with antibodies against (specific for derivation of the hindgut and intestinal intermediate) CDX-2. It can be used as a biomarker for differentiation of Barrett’s epithelium normal esophageal epithelium can be increased in Barrett’s esophagus has been shown and The protein AGR2.

Development of dysplasia: Initial diagnosis of Barrett’s esophagus and receive monitoring annual to detect changes that indicate that the risk of progression of cancer is high affected individuals but it appears. There is considerable variation in the evaluation of dysplasia among pathologists. In recent years, GI pathology and social Gastroenterology recommend you to be confirmed by the pathology fellowship GI trained at least two before the definitive treatment for the patient’s diagnosis of any of the high-grade dysplasia in Barrett You.

It is a malignant disease of the esophagus (esophageal cancer) or esophageal cancer. Various subtypes, there are adenocarcinoma and squamous cell carcinoma mainly. Squamous cell carcinoma cells derived from the line of the upper esophagus. Adenocarcinoma arising from glandular cells located at the junction of the esophagus and stomach. This leads to symptoms usually, dysphagia (difficulty swallowing), such as pain, esophageal tumors diagnosed by biopsy. Tumor localization and small will be treated with curative intent surgery. Larger tumors can be operated possibility is to treat the palliative care is high, their growth can be delayed by a combination of chemotherapy, radiation therapy or still. In some cases, radiation therapy and chemotherapy, can be large tumor of these triggers. Extent of the disease, and the prognosis depends on the medical problems of the other, but usually relatively low.